Part 4: The Story of “A”

This is, as the title suggests, one in a series of posts, almost entirely derived from emails from her family that they send me periodically to keep us up-to-date.

At the end of this post, and in a few minutes all the others, is a standard block of text with links to each part of the story of this child, as well as some additional information.

———–

From the child’s father:

“It has been over two years now since we began treating Crohn’s disease in our daughter, “A”, using helminthic therapy.

Specifically human whipworm, from Autoimmune Therapies, and she is today doing better then ever. She was around 21 months old when we started helminthic therapy, she had been diagnosed at 14 months of age, and had not responded to any attempted treatment of the disease, except steroids.

She is now over three and a half, and is as happy, healthy, and as beautiful as any parent could want from a child.

Two years ago my wife and I could have only hoped the future should be so bright for her, and us.

A has now taken four doses of the helminths, and each time her condition has only improved.

I can assure you it was not a straight line to good health, but rather a gradual improvement. Like any good, long term investment, there were setbacks along the way. Despite our better judgment, every time there was blood or diarrhea, in the back of our minds, we would wonder if it was the beginning of a major flare, one that would require the drugs we tried so hard to avoid for her.

But the reality was that it never even came close to that. There is no doubt she is doing better now then a year ago, and certainly two years ago. She continues to gain weight, in fact she is 34 pounds, and her stools continue to improve. We have even begun introducing different foods to her diet, with fantastic results.She can play endlessly with her sisters, is as cheerful as could be, and she is even a little chubby, something we’ll take any day of the week over the alternative.

She has not taken any medication for the Crohn’s disease since shortly after she began helminthic therapy.

Suffice to say, treating our little girl with helminthic therapy was the single best decision we could have made, given the circumstance. The treatment has enabled her to live a normal life with Crohn’s disease, rather then one riddled with pain and fatigue, pills, injections, and steroids.

It is not lost on our family, the thought that today we can focus on teaching “A” to read, and swim, and good manners, rarely worrying or even thinking about the fact that she has Crohn’s disease, instead of living in the bleak future we imagined for her, and us, two and a half short years ago.

I’m proud of what we did for her, and we’re thankful to Autoimmune Therapies for the opportunity to do it.”

End of email.

As it happens I am proud too, particularly of those who work with me to do this. I talk a lot, too much perhaps in the past, of the sacrifices my family has made. Far too little has been said about the team working with me.

All, in different ways, are making very considerable sacrifices to be able to make sure people like “A” continue to get the probiotics they need. Our chief scientist, who had a very good career before I came along, has essentially sacrificed that to peruse this. That is just one easy example to identify and explain.

One day soon I hope that it will be possible to acknowledge their courage, the risks and sacrifices they have made, and to do so completely publicly. I am the figurehead for a group of people who are all intelligent, hard-working, dedicated, principled and very high-integrity individuals.

All intelligent enough to not want their name to appear on my blog.

Here’s to hoping that will one day change and their accomplishments and courage can be lauded publicly.

Links to rest of series on “A”

“A” was under 2 years old when diagnosed with Crohn’s Colitis, and the disease appears from the family’s descriptions to have been severe and aggressive. They approached us when the recommendation for treatment from the child’s Gastroenterologist was one of the biologics, either Remicade or Humira, I cannot remember which.

Below are links to each of the four posts, so far, which for the most part are just emails from the child’s dad on “A’s” progress, and his thoughts and observations.

Managing the links between the posts has become cumbersome, so I have created this standard block of links to tie the story together, explain the context if someone happens upon one of the posts and does not realise they are part of a series, and will probably make a static page to aggregate the whole thing.

Part 1: Part 1 of the story of “A”

Part 2: Part 2 of the story of “A”

Part 3: Part 3 of the story of “A”

Part 4: Part 4 of the story of “A”

The context of helminthic therapy and the environmental diseases it can be used to ameliorate

I want to emphasise that I believe what we are doing exists in a much broader, well-established context.

The diseases we are trying to work with are all environmental in origin. The hygiene hypothesis essentially says that because we have impoverished the environments defined by our bodies by reducing the variety of organisms that populate us, we are getting sick.

Helminthic therapy is an attempt to restore health by remediating the ecosystem formed by the subject’s body. As in the reintroduction of wolves to control deer populations.

I believe that the most important, eventual, outcome of what we are doing will be to get mankind to see that our health is intricately intwined with our environment. That hundreds of millions of people are already sick right now because of anthropogenic environmental change.

That the environment, our ecosystem, is not something up in the sky or separate from us. That it is part of us, and intricately connected with us, our health, our daily lives, that we are component parts of one integrated, dynamic system.

That the ecosystems defined by our bodies and immediate environment, and our daily habits, have been so damaged that hundreds of millions of people are living lives limited by pain, fear and suffering.

If we succeed in that then a profound change in human behaviour towards our planet will occur. Because everyone will be conscious of their direct stake, theirs or their children’s health, in the health of the planet as an immediate phenomena. Not as some distant possibility that we might be able to put off by using the recycling bins.

That there are not ecosystems, except as artificial concepts. There is an ecosystem, and everyone”s health depends on it in profound and immediate ways, because we are all part of it.

We are the ecosystem. I am the ecosystem. You are the ecosystem.

Further, right now, our species in the industrialised and industrialising world, is under enormous selection pressure. Those with MS or Crohn’s, just two instances, will be much less likely to choose to procreate.

Ironically it is likely that many of the diseases we can address with helminthic therapy arise out of genetic adaptation to parasite/microbe rich environments. So in a sense the best adapted specimens, the very latest genetic models of humans, are those experiencing the worst consequences of environmental change.

We are witnessing not just the extinction of various species, but also a strong and rapid change in mankind’s genetic makeup.

I recognise that we should not attempt to “boil the ocean” as a friend used to put it, but I think if we frame this correctly we will find more allies than at first it might appear, and be able to present the concept of what we want to achieve in a more recognisable, and palatable, framework. We can just fit in, perhaps, rather than trying to present something entirely alien. If we are another environmental cause our pool of allies increase, and our messages are easier to understand, fit within a contextual and conceptual framework that is familiar.

That really is it for a while, enjoy your summers. Get outside, get dirt under your fingernails, get some sunshine, and get some river water down your nose.

Part 2: Follow up on progress of “A”

This is, as the title suggests, one in a series of posts, almost entirely derived from emails from her family that they send me periodically to keep us up-to-date.

At the end of this post, and in a few minutes all the others, is a standard block of text with links to each part of the story of this child, as well as some additional information.

———–

I just got a fantastic, cheering follow-up email from the dad of “A” whose experience with severe Crohn’s, as a two year-old, and her response to whipworm for her problems are described in my previous post, and now here:

Here is his follow up email to me:

Quoting: We had the colonoscopy done yesterday with amazing results. The doctors first words to us after completion were “I’m now a believer in this therapy”. “A” had absolutely no signs of Crohn’s anywhere. She said someone else looking at her would think there was not a thing wrong with her. The worms were alive and kicking, and she gave us some pictures. [A’s Mom] and I couldn’t be happier, we wanted to jump and shout. The doctor said we should get more worms, and that the biopsies should be in within two weeks. She seemed very pleased as well.” end quote.

Pretty cool, eh?!

Of course this is remission, not cure, so if she loses her helminths she would get sick again, but I for one could not be happier.

Links to rest of series on “A”

“A” was under 2 years old when diagnosed with Crohn’s Colitis, and the disease appears from the family’s descriptions to have been severe and aggressive. They approached us when the recommendation for treatment from the child’s Gastroenterologist was one of the biologics, either Remicade or Humira, I cannot remember which.

Below are links to each of the four posts, so far, which for the most part are just emails from the child’s dad on “A’s” progress, and his thoughts and observations.

Managing the links between the posts has become cumbersome, so I have created this standard block of links to tie the story together, explain the context if someone happens upon one of the posts and does not realise they are part of a series, and will probably make a static page to aggregate the whole thing.

Part 1: Part 1 of the story of “A”

Part 2: Part 2 of the story of “A”

Part 3: Part 3 of the story of “A”

Part 4: Part 4 of the story of “A”

Recent test results for Jasper Lawrence

I am the primary reservoir for production of doses of hookworm and whipworm for AIT’s version of helminthic therapy, and recently there has been some speculation as to my current status re infection with Hepatitis, HIV, etc.

As you can see (you can download the test results here: “Jasper Test Results 10-2010.pdf”) I am negative for everything I was tested for. I had these tests in early October, 2010, they sent the letter at the end of the month. Being slow to post them was simply a matter of losing a letter in a move and then the holidays preventing my getting a replacement copy.

Although I think only a handful of people have ever asked me about such test results (in over three years of being in business providing hookworm and whipworm) those that do are very interested in the results. Perhaps others that are very interested don’t mention it for some reason? As I explain later, I am not sure such concern is appropriate.

Part of the delay posting these results was a desire to combine the Strongyloides results with those just posted in one post, but I have given up waiting for the letter. I have of course called multiple times about getting a copy but I am still waiting. We have also had a lot of problems with mail here for the last month because of the weather, so it is probable it was lost in transit. I will post it as soon as I get it, which will probably be tomorrow now I have relented and put these results up.

The only value in the test is to reassure people, falsely I would argue. Anyone preparing doses of this type for other people has to take steps as if the host is infected with everything, to do otherwise would be irresponsible.

The reasons for this are manifold.

First, you cannot test for every possible pathogen. I doubt I have enough blood for such a comprehensive panel, even if I had the money.

Secondly, a negative test result, unless the disease is an exotic, hard-to-encounter-unless-you-travel-to-some-weird place, organism like Strongyloides, cannot be entirely relied upon because most tests are for antibodies, not for the actual pathogen.

So there is inevitably a period of time, referred to as the Window, in someone recently infected who carries one of these diseases where they are not yet producing any, or sufficient, antibodies to show up on a test.

If you are at all familiar with the HIV test you already know this. The interval between exposure to HIV and being able to test positive is up to six months, and in rare cases say when there is coincident Hepatitis C exposure (or use of prophylactic therapy), even longer. Even if you are being tested monthly, or more frequently, for every human disease going, you still do not know whether or not you have picked up something since your last test, or if they are in the Window period.

Third, some diseases cannot be tested for, although the pathogen has been identified.

Fourth, some diseases clearly have an infectious component, but that vector or agent has yet to be identified.

So the results have no effect on dose preparation, and although it is reassuring to know that your reservoir is not a cesspool of human disease such reassurance is illusory.

What you should really be concerned about is whether the person preparing the dose has the requisite knowledge, skills and experience, and is caring and attentive each and every time they are in the lab.

After all if GlaxoSmithKine can screw it up in a multi-million dollar facility staffed with PhDs and highly trained technicians, who presumably were being inspected by the FDA periodically, then the most important factor has to be the professionalism and care of the person preparing the doses: http://business-ethics.com/2010/10/26/1740-glaxosmithkline-to-pay-750-million-fine-whistleblower-to-get-96-million/

Having said all that if it is important to you I am happy to submit to any test you desire, at any time, so long as you are willing to pay for it if you want me tested outside our normal schedule of once every two months, for the diseases given during organ donation.

Thanks,

Jasper

What is helminthic therapy?

Helminthic therapy: the reason for this site

First, a nit. Helminthic therapy (hell min thick) is the correct term for treatment with helminths, not the term worm therapy (see reasoning here) It is certainly the term used by scientists and those in the know, so if you want to find good information you will have to use the term scientists use. Any research into the epidemiology of various diseases, or human or animal studies will refer to helminths or helminthic. So if, for instance you want to find read the original science about helminthic therapy and your disease you will have to use “helminth + [your disease name here]” to find anything useful.

Pubmed is a great resource for peer-reviewed papers on medical research and is published and maintained by the National Institutes for Health. End of nit.

Because I pioneered the availability of helminthic therapy based on the use of symbionts with humans as their definitive hosts I thought those interested in helminthic therapy might be interested in knowing more about the person responsible for taking it out of the research laboratory and making it available to the public.

So this site, when finished, will provide a short biography so that you can understand my background and how I came to be doing this rather strange business, as well as providing links to other sites and businesses I have been involved in over the years.

Since most people’s interest in me will be in connection helminthic therapy I will concentrate on posting about that.

What is Helminthic therapy

Helminthic therapy involves deliberate infection with or exposure to helminths or their ova.

Here are some useful links for those of you interested in the science:

Autoimmune Therapies website (check out the various pages devoted to particular diseases, as well as the About page, Safety page, Links and News.

Helminthic therapy is a technique for treating the “modern diseases” involving immune dysregulation (including autoimmunity) and chronic inflammation, that increasingly afflict the populations of developed or developing countries and which are rare or unknown in populations living in the kinds of conitions in which humans evolved.

Helminthic therapy is an attempt to restore some of the organisms that we co-evolved with, that shaped our immune system. Briefly, helminths educate our immune system through exposure early in life, and while we host them down regulate our inflammatory response. In the west where helminths are almost unknown the result is large numbers of people with poorly regulated, over active immune systems and an explosion of diseases involving chronic inflammation.

Disease like allergies and asthma, Crohn’s disease and multiple sclerosis, ulcerative colitis, psoriasis, and Sjögren’s Syndrome, are almost unknown in the developing world, largely it is now believed because helminth infection, and infection with a much larger variety and frequency of various protozoa and bacteria, is still so common.

Helminths, like any organism that lives in or on us, has to prevent their destruction by our immune system, and have evolved ways to turn our immune systems down. Because helminth infection, with multiple helminths, used to universal throughout our evolutionary history, our immune systems have evolved to account for their anti-inflammatory effect. Remove helminths, or worms, and their affect on our immune systems, and the result is an out-of-control immune system much more prone to chronic inflammatory reactions, causing allergies, asthma, Crohn’s disease, multiple sclerosis, etc., etc., etc.

This might sound like a repulsive concept, and it is, but consider that about 90% of the cells in or on you right now are not self tissue. This is possible because bacteria, viruses and moulds are so much smaller than human cells.

In 1976 a researcher called Turton infected himself with  hookworm (a type of helminth) so that he would have a reservoir of hookworm to study, and reported unexpectedly that his lifelong seasonal allergies disappeared so long as he was infected with the hookworms.

But, the seemingly radical idea that helminths (probiotic worms) might be related in some way to asthma predates Turton by sixty-three years. In 1913 Herrick wrote that ‘Common to both bronchial asthma and helminth infection is an increase of the eosinophils (eosinophils in a normal person indicate infection with a helminth) of the blood. One day we’ll ask the significance of this eosinophilia in this association’.

Unfortunately for allergy and asthma sufferers it wasn’t until 1986, almost 75 years later, with the publication of the hygiene hypothesis by Godrey in the Lancet that investigation of this idea got underway.

In 1986 Godfrey proposed that a lack of exposure to infectious organisms in childhood was responsible for the increase in allergies, and demonstrated this with a study of large families. He showed that children in large families were less likely to develop allergies. He reasoned that they were exposed to more childhood diseases and that this was responsible for their reduced rates of allergy. His theory came to be known as the Hygiene Hypothesis.

Of course many immunological disorders can be triggered by various immune insults, including infections or disease. So the Hygiene Hypothesis was later refined based on the work of hundreds of studies to become the Old Friends Hypothesis.

The Old Friends Hypothesis states that by introducing sewers, antibiotics, shoes, clean drinking water and vaccinations, we have reduced by a very large amount the variety and quantitie of benign infectious organisms that we are exposed to. Particularly helminths, or worms, that have been entirely eliminated in the industrialized world.

By elminating worms, bacteria and protozoa from our bodies we have deprived our immune systems of the stimulation and “practice” that it evolved to account for. Infection with worms and protozoa and a much larger variety and quantity of bacteria and viruses used to be universal. Their elimination deprives our immune systems of the kind of stimulation it evolved to account for as a certainty. Without that training and presentation of appropriate targets, ones it evolved to “expect”, our immune system instead attacks our own tissues (this is autoimmunity) or benign pathogens like pollen and cat dander causing tissue damage (this is immune dysregulation).

By these definitions diseases like asthma and allergies are not autoimmune diseases, but most people don’t know, or care (nor should they), about the difference. In fact their is a debate within the scientific community right now about adding another classification to encompass non-autoimmune diseases involving chronic inflammation because these are in fact the most common types of immunological diseases. Very few diseases that are called autoimmune diseases by lay people actually meet the criteria for autoimmunity.

Helminthic therapy works by giving our bodies and immune systems benign, appropriate targets that allow our immune system to fulfill the purpose for which they evolved. Helminthic therapy works by giving the immune system the right targets and “distracting” our immune system from attacking the wrong things: us (autoimmune diseases) and pollen or cat dander (allergies or asthma), or the food we eat (Crohn’s, UC, IBS, Celiac disease), or our nerves (multiple sclerosis), or thyroid (Hashimoto’s thyroiditis) or our mucus membranes (Sjogren’s Syndrome), etc.

Helminths also secrete or excrete various immuno modulatory molecules that have profound impacts on the functioning of the immune system. Simply put the immune system of a person infected with hookworm or whipworm appears to be better regulated, produce fewer pro inflammatory components, and more anti inflammatory components.

Although deliberately infecting oneself with parasites is at first a strange and hard to accept concept when one thinks about it not being infected with these organisms is what is strange. We evolved with a much larger variety of organisms, including helminths, inhabiting our bodies throughout our lives. The potential application of worm therapy is incredibly broad. Most of our modern diseases, even things like depression and autism for just two examples, involve inflammation as a causative factor.

The impact of helminthic therapy on inflammation is profound. The most extreme inflammatory reaction is anaphylaxis in which the body’s immune system insulted by something like a bee sting, goes into uncontrolled overdrive and if untreated will kill. Infection with helminths has such a profound effect on the immune system that those hosting helminths do not ever get anaphylaxis, so the impact on the immune system of helminths is profound. Anaphylaxis is an extreme form of allergy, most commonly associated with peanut allergy.

I used to suffer from awful asthma and allergies, to the extent that I could only breath comfortably if using oral prednisone in such high doses that I developed lipomas and became for the first time in my life very obese.

My aunt told me about a documentary she had seen on the BBC about worms and asthma and after investigating it and trying everything I could think of to obtain hookworm (one of the worms used in helminthic therapy) I went first to Cameroon and later to Belize to obtain hookworms.

Since I founded Autoimmmune Therapies in 2006 we have treated dozens of clients with a variety of diseases: allergies (food and airborn), multiple sclerosis, Sjogren’s Syndrome, psoriasis, ulcerative colitis, Crohn’s disease, and autism. The results have been remarkable, far better than those possible using modern drugs. Why this technique is not more widely available or known is a constant source of wonder for me.

However a small industry has grown up around helminthic therapy, including providers and support groups on Yahoo and Facebook.

More to come later.

Jasper Lawrence